Search results for "La icp ms"
showing 9 items of 9 documents
Application of LA-ICP-MS as a rapid tool for analysis of elemental impurities in active pharmaceutical ingredients.
2014
The control of inorganic contaminants in active pharmaceutical ingredients has a significant role in the quality control of drug products. The concentration limits for metal residues in drug products have been defined by various regulatory guidelines. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is a powerful and fast analytical technique for multi-elemental analysis. A disadvantage in using LA-ICP-MS method is the lack of matrix reference materials for validation and calibration purposes. This article focuses on the handling strategy of laboratory-made matrix calibration standards for the quantification of elemental impurities in an active pharmaceutical ingredie…
XRF and LA-ICP-MS studies of gold and silver artefacts from a 12–13th century CE tumulus in Senegal: Implications for the medieval African gold trade
2019
Abstract Silver and gold artefacts from a 12–13th c. CE tumulus in Senegal were recently analysed by means of XRF and LA-ICP-MS. The identification of major, minor and trace elements allowed gaining a rare insight into the composition of precious metals circulating in that part of Africa in medieval times. The results show that all objects were made of polymetallic alloys. Comparisons with analyses from other West African as well as North African and European silver and gold artefacts suggest that the metal from the studied objects most probably originate from outside West Africa. At least in the case of the gold artefacts, this is quite surprising, as we expected to come across pure West A…
Forensic investigation of brick stones using instrumental neutron activation analysis (INAA), laser ablation-inductively coupled plasma-mass spectrom…
2009
Abstract Brick stones collected from different production facilities were studied for their elemental compositions under forensic aspects using laser ablation–inductively coupled plasma–mass spectrometry (LA–ICP–MS), instrumental neutron activation analysis (INAA) and X-ray fluorescence analysis (XRF). The aim of these examinations was to assess the potential of these methods in forensic comparison analyses of brick stones. The accuracy of the analysis methods was evaluated using NIST standard reference materials (679, 98b and 97b). In order to compare the stones to each other, multivariate data analysis was used. The evaluation of the INAA results (based on the concentrations of V, Na, K, …
Forensic comparison of PVC tape backings using time resolved LA-ICP-MS analysis
2019
Abstract Adhesive tapes are common tools for criminal acts such as the construction of improvised explosive devices. Hence, tape samples can be used as evidence to link a suspect to a scene of crime or different crime scenes to each other. A set of 87 black electrical tapes was the subject of a study evaluating a LA-ICP-MS method for the characterization of tape backings regarding their elemental composition in a forensic context. LA-ICP-MS is a powerful tool in forensic investigations due to fast, quasi nondestructive analysis of small samples and detection or determination of elements up to the ultra-trace range. In this study, the development of a semiquantitative LA-ICP-MS method for fo…
Assessment of Five Monazite Reference Materials for U-Th/Pb Dating Using Laser-Ablation ICP-MS
2019
Monazite is a common accessory phosphate mineral that occurs under a wide range of pressure and temperature conditions in sedimentary, metamorphic and igneous rocks. Monazite contains high amounts of Th and U, rendering single monazite grains suitable for in-situ U-Th/Pb dating using laser ablation inductively-coupled mass spectrometry (LA-ICP-MS). Two key aspects of monazite dating that are critical for accurate age data with maximum precision are (i) optimized instrumental conditions to minimize analytical scatter and (ii) a well characterized reference material to ensure the accuracy of the obtained aged. Here, we analyzed five monazite reference materials (USGS 44069, 94-222, MAdel, Moa…
Non-Matrix-Matched Calibration for the Multi-Element Analysis of Geological and Environmental Samples Using 200 nm Femtosecond LA-ICP-MS: A Compariso…
2014
LA-ICP-MS is one of the most promising techniques for in situ analysis of geological and environmental samples. However, there are some limitations with respect to measurement accuracy, in particular for volatile and siderophile/chalcophile elements, when using non-matrix-matched calibration. We therefore investigated matrix-related effects with a new 200 nm femtosecond (fs) laser ablation system (NWRFemto200) using reference materials with different matrices and spot sizes from 10 to 55 μm. We also performed similar experiments with two nanosecond (ns) lasers, a 193 nm excimer (ESI NWR 193) and a 213 nm Nd:YAG (NWR UP-213) laser. The ion intensity of the 200 nm fs laser ablation was much l…
Characterisation of Apatites as Potential Uranium Reference Materials for Fission-track Dating by LA-ICP-MS
2015
We report homogeneity tests on large natural apatite crystals to evaluate their potential as U reference materials for apatite fission-track (AFT) thermochronology by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). The homogeneity tests include the measurements of major element concentrations by electron probe microanalysis (EPMA), whereas for U concentration, isotope dilution (ID) ICP-MS and laser ablation (LA) ICP-MS were employed. Two apatite crystals are potential reference materials for LA-ICP-MS analysis: a 1 cm3 fraction of a Durango crystal (7.5 μg g−1 U) and a 1 cm3 Mud Tank crystal (6.9 μg g−1 U). The relative standard deviation (1 RSD) of the U concentrat…
Comment on "Displacement along the Karakoram fault, NW Himalaya, estimated from LA-ICP-MS U Pb dating of offset geologic markers" published by Shifen…
2013
International audience; Field evidence for syn-deformation migmatization and crystallization along the Karakorum fault contradicts the study of Wang et al. (2012). The ages of such magmatic rocks provide minimum ages for the onset of deformation at similar to 23 Ma in North Ayilari and similar to 19 Ma in Tangtse. The onset of deformation at 12 Ma in the Ayilari range inferred by Wang et al. (2012) from a muscovite Ar/Ar age is a cooling age, thus only a minimum age. The similar to 60 Ma granodiorite bodies, the ophiolitic rocks and the south Kailash thrust that are correlated across the fault to provide a 52 +/- 2 km finite offset do not define reliable piercing points. Such observations a…
Garnet as a monitor for melt–rock interaction: Textural, mineralogical, and compositional evidence of partial melting and melt‐driven metasomatism
2021
International audience; In this study, we focus on a partially melted garnet-bearing granulite from the Salvador–Esplanade Belt (Salvador da Bahia, Brazil), and examine the behaviour of major and trace elements during partial melting and melt-driven metasomatism. Phase equilibria modelling and U–Th– Pb geochronology show that the sample underwent partial melting during the heating segment of the decompression path from ~1.2 GPa and 675–700° C to ~0.8 GPa and 790°C at c. 2.06 Ga. During the final stage of decompression, from 0.8 to ~0.5 GPa, physical segregation of melt resulted in the establishment of chemical potential gradients and mass transfer between the host granulite and the leucosom…